Ulcerative Colitis (UC) Treatment Market: Increasing Ulcerative Colitis Patients Globally to Drive the Market
Wilmington, Delaware, USA, Transparency Market Research Inc.: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that involves chronic inflammation of the colon or large intestine. It causes long-lasting ulcers (sores) and inflammation in the digestive tract and usually affects the innermost lining of the colon and rectum. Symptoms of the disease include dehydration, pus or blood in the diarrhea, abdominal pain, fever, and painful, urgent stools. Although the exact cause of the disease has not been identified, the abnormal activation of the immune system in an individual’s intestines leads to portions of ulceration and chronic inflammation of the colon.
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Ulcerative colitis can be classified into ulcerative proctitis, proctosigmoiditis, left colitis, pancolitis or universal colitis and fulminant colitis depending on the degree of inflammation and its location. Inflammation in ulcerative proctitis is limited to the rectum. In proctosigmoiditis, inflammation is seen in the sigmoid colon and rectum. Inflammation of the rectum extending to the left colon occurs in left-sided colitis. In universal colitis or pancolitis, the inflammation affects the entire colon. Fulminant colitis is a serious but rare form of universal colitis.
The increase in the number of ulcerative colitis patients globally is a significant factor driving the expansion of the ulcerative colitis treatment market. According to a report published in the Crohn’s & Colitis Foundation of America (CCFA), approximately 1.6 million people in the United States were affected by IBD in 2014, with 70,000 new cases reported each year. Of the total number of people with IBD in the United States, 907,000 had ulcerative colitis.
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The number of new UC cases would increase rapidly in the newly industrialized countries of Eastern Europe, South America, Africa and Asia. Increased use of antibiotics, westernized diets, increased exposure to pollution and improved hygiene are some of the factors playing a central role in the increased incidence of UC in developing countries compared to developed countries. The greatest increase in the incidence of these conditions has been reported in countries like Japan, India, China, etc.
New collaborations and partnerships between biopharmaceutical companies are also helping to provide new treatment options for the management of UC. In February 2018, Cook Biotech Inc. entered into a new partnership with Regentys to develop a novel treatment for UC. Pursuant to the agreement, Cook Biotech will develop and manufacture Regentys ECMH Rectal Solution (extracellular matrix hydrogel), a patented, non-surgical hydrogel therapy for patients with ulcerative colitis. In December 2017, Roche announced a collaboration agreement with Boehringer Ingelheim for the discovery and manufacture of novel LNA (locked nucleic acid) oligonucleotides used in the management of inflammatory bowel diseases such as UC.
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The global ulcerative colitis treatment market can be segmented on the basis of treatment, end-user, and geography. In terms of treatment, the ulcerative colitis treatment market can be divided into
non-surgical and surgical. The non-surgical segment can be categorized into 5-aminosalicylic acid, corticosteroids, immunosuppressants, and others. Based on the end user, the ulcerative colitis treatment market can be divided into hospitals, outpatient surgery centers, and clinics.
In terms of geography, the global ulcerative colitis treatment market can be segmented into North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa. North America dominates the global ulcerative colitis treatment market due to a large population with ulcerative colitis and continuous funding for the development of new therapies for the treatment of the disease.
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North America is followed by Europe. The injection of fresh capital by private equity firms into companies involved in researching innovative treatment methods for UC is likely to propel the ulcerative colitis treatment market in Europe. In May 2018, Sublimity Therapeutics Limited, a specialty pharmaceutical company, announced that it had successfully raised US$64 million from investment firms led by Longitude Capital, OrbiMed and HBM Healthcare Investments. Proceeds from the capital raised will be used for the clinical development of STI-0529 for the treatment of moderate to severe UC.
The major players operating in the global ulcerative colitis treatment market are Boehringer Ingelheim, Cook Biotech Inc., Pfizer, Inc, Regentys, and Sublimity Therapeutics Limited.
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